2007-10-05

• [http://www.biologynews.net/archives/2007/10/04/brown_researchers_make_major_signal_transduction_discovery.html brown researchers make major signal transduction discovery] -- Biology News Net

{{| scientists have long known that phosphorylation, an amino acid modifying process in proteins, is critical for switching receptors on and off on the surface of cells. Chin and his team studied how type 1 interferon binds to a receptor complex, known as the IFN-α receptor, on the cell surface to trigger an immune response. Chin and his team found that acetylation, another chemical process that modifies amino acids, plays a central role in activating interferon receptors.

Interferons play a crucial role in the body’s defense against infection and uncontrolled cell growth. Type 1 interferon is widely used to treat hepatitis B and C and cancers such as melanoma and leukemia.

“This is a major discovery in the field of signal transduction,” Chin said. “Tyrosine phosphorylation has so far been considered the major player in signal transduction. But what we discovered challenges this concept. We found another player – acetylation – in the process.” |}}

• : 그 동안 signal transduction의 작용은 phosphorylation에 의해서 일어나는 것으로 알고 있었는데, acetylation에 의해서도 신호가 전달된다는 내용으로 항암제와 같은 치료제가 잘 작용하지 않는 이유 중 하나일지도 모른다.

2007-10-04

• 떡하니 다른 분의 블로그에 답글을 달때, 항상 이곳 주소를 기입하면서도 계속 글을 남기지 않은 것에 대하여 반성한다. 단순히 남에게 보여지기 위한 기록도 좋은 것은 아니지만.

• [http://pbeltrao.blogspot.com/2007/10/bioblogs-15.html Bio::Blogs #15] -- Bio::Blogs

  • : 이번 내용에서는 각종 Bioinformatics관련된 학회에 관한 내용들이 들어가 있다. 해외에 갈 수 없는 상황에서 유용한 정보를 얻을 수 있을 듯.

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